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When an individual subscriber fails to click or open an email for an extended period, he becomes an inactive subscriber, a dormant subscriber, a non-responder, or a non-engaged subscriber.
Factors like the type of product or service you are promoting and your sending frequency determines how much time it takes for a subscriber to become inactive.
You can decide the duration of an inactive period and segment inactive subscribers in line with that duration. However, if there is no response from these inactive subscribers after sending a few re-engagement messages, it is safe to archive them or remove them from the list altogether.
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